This study aims to produce PISA-based literacy reasoning questions using the Covid-19 context. This study uses the collaboration model of Borg and Gall (2007), Zulkardi (2006) and Tessmer (1993) with two stages, namely preliminary and formative evaluation. The data collection process was carried out through literature studies, questionnaires, interviews, assessment sheets and tests. The results of this study were in the form of a collection of literacy reasoning questions in the context of COVID-19 which were compiled using the Inquiry method. It can be seen from the results of the research conducted, that the literacy reasoning questions made are feasible and practical because they can produce answers that vary according to the level of difficulty of the questions.